![]() ![]() There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. ![]() Printed on acid-free paper Springer is part of Springer Science+Business Media (Preface 2012 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. ISSN 0065-2598 ISBN 978-9-4 e-ISBN 978-9-1 DOI 10.1007/978-9-1 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011945106 © Springer Science+Business Media B.V. Gemelli 8 00168 Rome Italyīruno Giardina Institute of Biochemistry and Clinical Biochemistry School of Medicine, Catholic University Largo A. Patrizia Bottoni Institute of Biochemistry and Clinical Biochemistry School of Medicine, Catholic University Largo A. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, ItalyĮditors Roberto Scatena Institute of Biochemistry and Clinical Biochemistry School of Medicine, Catholic University Largo A. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. ![]() Advances in Experimental Medicine and Biology Editorial Board: IRUN R. ![]()
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